The Western blot in Figure5A shows the presence of zonulin/preheptaglobin-2 in glioma C6 CM and not in astrocyte CM.Figure S3 D and figure 5B shows how the elimination ofzonulin/preheptaglobin-2 from glioma C6 CM, by immunoprecipitation with an specific antibody,diminished in a 36% the transmigration of ReNcell CX across RBMECs monolayers. This evidence concerns the gene HP and central nervous system cancer.