It is thus noteworthy that glioma C6 CMinduced in RBMECs, at the sites of ReNcells CX transmigration, a reduced expression of occludin andclaudin-5, similar to that observed for claudin-5 in these cells upon melanoma cells transmigration[43] and for occludin in the brainendothelial cell line GP8/3.9 upon monocyte transmigration [44]. The gene discussed is CLDN5; the disease is melanoma.