The strong expression of claudin-5 found inthe tumor area was expected since glioma growth is angiogenesis dependent [46], while the striatum region of the brain, where the lesion wasperformed for the injection of ReNcells CX or vehicle, is not as highly vascularized as otherregions like the cerebellum, therefore explaining the minimal expression of claudin-5 found invehicle and contralateral sections. This evidence concerns the gene CLDN5 and neoplasm.