EGFR and neoplasm: In breast cancer cells, EGFR signaling activation can induce epithelial to mesenchymal transition (EMT), favoring invasion and metastasis along with increased expression of genes associated with self-renewal, increased percentage of stem-like cells, in vitro sphere formation and in vivo tumor growth (Del Vecchio et al., 2012; El-Haibi et al., 2012).