EGFR and head and neck squamous cell carcinoma: Naïve EGFR addiction reveals in locally advanced SCC (for example, SCCHN, and the SCC histological subtype of NSCLC), mostly in tumors having EGFR over-expression, as evidenced by the clinical responses observed in patients upon treatment with anti-EGFR agents (Bonner et al., 2006; Pirker et al., 2012).