On a cautionary note, most pilocytic astrocytomas (a distinct diagnosis, but related to anaplastic astrocytoma) carry RAF1 or BRAF rearrangements; thus it is possible that the D538-MG cell line (harboring BCL6/RAF1) was actually derived from a misdiagnosed pilocytic astrocytoma. The gene discussed is RAF1; the disease is anaplastic astrocytoma.