Many of these breakpoints corresponded to known gene fusions, including BCR/ABL1 in CML, FIP1L1/PDGFRA in eosinophilic leukemia, and NPM1/ALK in anaplastic large cell lymphoma (ALCL) (Figure S4). The gene discussed is NPM1; the disease is Chronic Eosinophilic Leukemia, Not Otherwise Specified.