We quantified the intensity of the signal of nuclear CUGBP1 staining in DM1 myoblasts transfected with SMAUG1 versus controls transfected with GFP, and we found that SMAUG1-transfected DM1 myoblasts show a significant decrease in the nuclear signal intensity compared to controls transfected with GFP (Figure 4D, p<0.0001). The gene discussed is SAMD4A; the disease is myotonic dystrophy type 1.