The most marked effect of HIV on the kinetics of CD4+ T-cells was found in the CCR5+ subset where HIV infection more than doubled modeled proliferation rates (5.16±4.51 versus 2.50±1.26%/d, HIV+ vs controls, P = 0.046, ratio (HIV dynamic factor) 2.07,Table 2). This evidence concerns the gene CD4 and HIV infectious disease.