These findings are reminiscent of other fibrillar prions that are poorly neuroinvasive, including 87 V [26], [27], mCWD [26], and vCJD in transgenic mice expressing human PrP [28], and may indicate that the common fibrillar structure effectively impairs a prion's ability to neuroinvade. The gene discussed is PRNP; the disease is variant Creutzfeldt-Jakob disease.