Several proteases have been implicated in the degradation of myelin proteins and the generation of immunogenic peptides in multiple sclerosis and experimental autoimmune encephalomyelitis (EAE) including calpain, trypsin 4, matrix metalloproteinase, myelencephalon-specific protease (MSP), plasminogen activators and cathepsin D [63-66]. The gene discussed is CTSD; the disease is experimental autoimmune encephalomyelitis.