NOD2 and Cowden disease: Carrying at least one NOD2 variant allele is associated with an ileocolonic (L3) localization (p=0.048) in the pediatric- and a trend to an ileal involvement alone in the adult-onset CD patients (38% versus 21%; p=0.06), while pediatric-onset NOD2 wild-type patients more frequently had a colonic involvement alone (p=0.048).