In keloids, the mechanotransduction pathways may involve the transforming growth factor-β (TGF-β)/Smad, MAPK, integrin, RhoA/ROCK, Wnt/β-catenin, and TNF-α/nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) pathways [42]. The gene discussed is TNF; the disease is keloid.