Although the results from these exploratory pathway analyses do not suggest that breast cancer risk is affected by combined variation in the genes that we examined from the KEGG “Toll-like receptor signaling pathway”, this study may have been limited to detect such an association given our sample size and the absence of some key genes within this pathway (such as MyD88, TLR1, and TLR2). This evidence concerns the gene TLR2 and breast cancer.