INS and Hyperglycemia: Glucose uptake into the cells is stimulated by insulin and leptin activating the JAK2/IRS/PI3K/AKT signaling pathway [103] and triggering the translocation of the GLUT4 from the cytosol to the cell surface [104] Downregulation of PI3K and AKT indicates an insufficiency of insulin to maintain the normal signaling [105] and downregulates the intake of glucose through GLUT4 in the muscles, which results in hyperglycemia [106].