For example, skewed inactivation has been reported in rearrangement and truncation mutations that result in a loss of function in the NEMO (IKBKG) gene, which is associated with incontinentia pigmenti, hypohidrotic ectodermal dysplasia, and other types of immunodeficiencies [20-22]. This evidence concerns the gene IKBKG and autosomal dominant hypohidrotic ectodermal dysplasia.