CD4 and neoplasm: Both the mouse model and the human tumor share the following features: (1) macrophages/microglia are more abundant at the tumor front than in its core, (2) T-cell infiltration is more prominent at the tumor front, (3) the majority of these lymphocytic cells are CD4 positive, (4) there are fewer vessels at the tumor front than in its core, and (5) the number of vessels is inversely correlated with their diameters.