Moreover, genetic dysregulation of the IL-33/IL1RL1 axis appears to be involved in conferring predisposition to several multifactorial diseases, such as Alzheimer’s disease [20], asthma [21], [22], [23], nasal polyposis [24], allergic rhinitis [25], and atopic dermatitis [26]. Here, IL33 is linked to early-onset autosomal dominant Alzheimer disease.