Using a rat model of endometriosis, Styer et al. [37] demonstrated that disruption of leptin signaling by administration of the pegylated leptin peptide receptor antagonist (LPrA) or nonfunctional leptin receptor (LeprdB) inhibits the establishment and development of endometriosis-like lesions that resemble peritoneal endometriotic foci. This evidence concerns the gene LEP and endometriosis.