Interestingly, a variant case of OFDS, that partially resembles OFDS type IV and type II (also known as Mohr Syndrome, OMIM 252100) shows a malformation spectrum including endocardial cushion defects, cleft palate and central polydactyly with bifurcated Y-shaped metacarpals of the forth digit [50] phenocopying Tbx2 loss-of-function in the mouse [17], [21], [51]. Here, TBX2 is linked to Orofaciodigital syndrome type 2.