Remarkably our biochemical and microscopical data show that both Grb2 and c-Cbl co-localized with wild-type EGFR and internalized Chlamydia (Fig. 7A+B), and this interaction was critical for infection, as infectivity was reduced 5-fold when an Y1068/1086 EGFR mutant was expressed (Fig. 7D), and this reduction is almost identical to the 5-fold reduction in rates of internalization previously measured for this EGFR mutant form [34]. Here, EGFR is linked to infection.