Complementing the ΔospI mutant with the Q142A or E105A/Q142A gene did not efficiently suppress IκBα-phosphorylation and IL8 mRNA production induced by ΔospI infection as with the wild-type OspI gene (Figure 3C, 3D and S4), which is consistent with the in vitro studies. The gene discussed is NFKBIA; the disease is infection.