let-7, known to target DAF-12 signaling and regulate lifespan in worms [127], has been implicated in Alzheimer’s disease by its demonstrated genetic interactions with the homolog of amyloid precursor protein (APP), APP-like-1 (apl-1) in worms, suggesting that Aβ peptide formation is under miRNA control in organisms other than mammals [111, 112]. Here, APP is linked to early-onset autosomal dominant Alzheimer disease.