Similar results were obtained with another breast cancer cell line (SK-BR-3) transiently transfected with WT MMP-8 and E198A MMP-8 (Fig. 1C), but this phenomenon was not seen on transient transfection into a non-cancerous breast epithelial cell line, HMT-3522 S1 (D). The gene discussed is MMP8; the disease is breast carcinoma.