It has been proposed that the relationship between SUA and physical activity is mediated by the latter’s effect on insulin sensitivity[39,44], although it has also been posited that elevated uric acid levels may have a causal role in the pathogenesis of insulin resistance[45], since elevated levels of uric acid decrease the bioavailability of nitric oxide, and insulin requires endothelial nitric oxide to stimulate glucose uptake in skeletal muscle[46]. This evidence concerns the gene INS and Insulin resistance.