AIM2 activation has been reported during infection with cytosolic bacteria or DNA viruses (Fernandes-Alnemri et al., 2010; Jones et al., 2010; Rathinam et al., 2010; Sauer et al., 2010) as well as during autoinflammatory syndromes such as psoriasis (Dombrowski et al., 2011). This evidence concerns the gene AIM2 and psoriasis.