AKT1 and prostate carcinoma: Dysregulation of its components, such as PTEN, PIK3CA, and AKT (PKB), is common in solid tumors including breast, colon, endometrial, and prostate cancers (Samuels et al., 2004; Zhao and Vogt, 2008; Dillon and Muller, 2010; Song and Salmena, 2012).