ERBB2 and breast carcinoma: Strikingly, neratinib showed promising activity in ERBB2-overexpressing breast cancers and could potentially be approved as a first-line therapy in locally advanced or metastatic ERBB2-overexpressing breast cancers (Chow et al., 2009; Limentani et al., 2009; Burstein et al., 2010; Awada et al., 2013).