TNFRSF1A and inflammatory response: In the present study, we investigated whether lentinan, a dietary β-1,3;1,6-glucan derived from Lentinula edodes, exerts anti-inflammatory activities using an in vivo and an in vitro model of gut inflammation, and we provide evidences that lentinan inhibits gut inflammation through modulation of TNFR1 expression in IECs.