Representative pathways involved xenobiotic metabolism (AhR and xenobiotic metabolism signaling, glutathione metabolism), cell cycle dysregulation (G1/S checkpoint regulation, cyclins and cell cycle, ATM signaling, estrogen-mediated S-phase entry), malignancy pathways (glioma and hereditary breast cancer signaling), Nrf2-mediated oxidative stress, and ten various intermediary and amino acid metabolism pathways. The gene discussed is ATM; the disease is central nervous system cancer.