MDM2 and liver cancer: We found that the pattern of cell cycle transcript upregulation in DEG datasets using RNA-Seq_DESeq shows similarities to low level genotoxic damage described in some rodent liver cancer models; for example, p53 IHC (immunohistochemistry) negative preneoplastic liver lesions stain positive for Gst-P and Mdm2 with either chronic diethylnitrosamine or AFB1 exposure in rats [53] and are often accompanied by increased in Slc7a11 [54], a cystine-glutamate transporter induced during GSH depletion and redox stress [55].