Importantly, we found that the expression levels of GRIM-19 and NDUFS3 were decreased level in the highly invasive breast cancer cell lines in comparison with that in the weakly invasive lines by screening of a panel of breast cancer cells (Figure 5), which support the role of mitochondrial complex I and even mitochondrial respiratory chain (RC) in the tumor cell invasion. Here, NDUFS3 is linked to breast cancer.