In addition, vascular endothelial growth factor (VEGF), the most common angiogenic factor in clinical tests, can lead to undesirable consequences such as hemangiomas and atherosclerotic lesions if expressed at too high a level in animal models [2], [3], [4], [5], [6], [7] even if VEGF concentrations become too high in extremely localized regions on a microscopic level [8], [9]. Here, VEGFA is linked to hemangioma.