Here we used the HOXB2 (human homeobox B2) gene, a member of the Antphomeobox family that encodes a nuclear protein with a homeobox DNA-binding domain, and a known gene associated with tumor growth and invasiveness [20], [21] as an example to illustrate how CMS is able to determine tumor specific methylation profiles for breast and endometrial cancers. Here, HOXB2 is linked to endometrial cancer.