Specifically, the distinct hypermethylation pattern of BRCA1, SNURF, GMTM2, NROB1, CDK11B, LATS2, HRAS, MAPK3, RPS6KA3 and EGR1 demarcate the cluster's methylation status of breast tumor (not cell-lines), along with HOXB13. Here, MAPK3 is linked to breast neoplasm.