In that context, C3 and its cleavage products, C3adesArg (aka acylation stimulating protein, ASP), complement C3a receptor (C3aR), tumor necrosis factor alpha (TNF-α), and toll-like receptors (TLRs), among others, are present in adipose tissue and, based primarily on mouse models, are proposed to impact adipose tissue functions, leading to insulin resistance. The gene discussed is C3; the disease is Insulin resistance.