Compared to WT controls, significant differences (p<0.0001) were detected in the cerebellum of 6–8 months and 10–12 months AD brain for mRNA expression of 3HAAO and ACMSD, significantly increased mRNA expression of QPRT was also shown in the cerebellum of 6–8 months (p<0.01) and 10–12 months (p<0.05) for AD mice. Here, QPRT is linked to Alzheimer disease.