CRF has been implicated in alcohol addiction because there is evidence that neuroadaptive changes triggered by a prolonged history of alcohol exposure lead to a chronically dysregulated CRF/CRF1 receptor (CRF1-R) system activity that, in turn may drive excessive and uncontrolled alcohol consumption motivated by relief of negative emotionality (Heilig and Koob, 2007; Koob, 2010; Breese et al., 2011). This evidence concerns the gene CRH and Addictive alcohol use.