TGFB1 encodes transforming growth factor beta-1 (TGFβ1), a protein with complex function, involved in several cellular processes from differentiation and proliferation to innate immunity, and has been studied in relation to many disorders including Alzheimer’s disease, cancer, Marfan disease, and heart disease (Waltenberger et al., 1993; Yamamoto et al., 1993; Dickson et al., 2005; Brooke et al., 2008). Here, TGFB1 is linked to early-onset autosomal dominant Alzheimer disease.