There is also evidence suggesting that activation of erythropoietin-producing hepatocellular carcinoma (Eph) receptors decreases interaction between Eph–PICK1 and instead favors the SR–PICK1 interaction, resulting in a subsequent increase in D-serine synthesis in cultured hippocampal astrocytes (Zhuang et al., 2010). This evidence concerns the gene PICK1 and hepatocellular carcinoma.