CXCL8 and Candidemia: The R753Q TLR2 polymorphism increased the risk for candidemia in one small study through decreased IFN-γ and IL-8 levels (Woehrle et al, 2008), and two SNPs in the TLR4 gene were shown to be a risk factor for candidemia through increased IL-10 production (Van der Graaf et al, 2006), but these observations were not replicated in a larger study of patients (Plantinga et al, 2012).