SNP rs6894869 was significantly associated with lipid particle size phenotype BMED and mapped to an intron of CTNND2, which functions in the same pathway as cadherins, plays a crucial role in CNS development [29] and is a partner of the Alzheimer disease-associated gene presenilin-1 [30]. This evidence concerns the gene PSEN1 and early-onset autosomal dominant Alzheimer disease.