We also found that while the intensities of phosphorylated STAT5A, a marker of JAK activities, did not correlate with the responses of our AML cell panel to JAK-i, the intensities of phosphorylated Ribosomal S6 (a marker of PI3K/mTOR pathway activation [36]) did correlate with resistance to this compound (Figure 7C). The gene discussed is PIK3CA; the disease is acute myeloid leukemia.