Even though a few angiolipomas and other PEComas arising in non-renal locations (that is, liver, lungs, and so on) have been reported to have patchy or negative reactivity for melanosome markers, recent reviews consider that 100 percent of renal EAMLs are positive for either HMB-45 or Melan-A [5,9-12]. This evidence concerns the gene MLANA and neoplasm with perivascular epithelioid cell differentiation.