This leads to the complement system, the kallikrein system, neutrophils and vascular endothelial cell activated, cell surface adhesion molecule expression, mast cell degranulation, tumor necrosis factor (TNFα), interleukin (e.g. IL-1β, IL-6, IL-8) and other cytokines signaling cascad style released,which triggered ECMO-related SIRS [14-17]. The gene discussed is IL1B; the disease is systemic inflammatory response syndrome.