ESR1 and neoplasm: In the Cox’s proportional hazards model, which included age, menopausal status, tumor size, nodal status, nuclear grade, ER, PgR, HER2 and Ki67, Aurora A mRNA expression proved to be a significant prognostic univariate parameter (P = 0.006) and multivariate factor (P = 0.027) for RFS (Table 2).