In a larger population of patients with LOAD in Switzerland, Papassotiropoulos et al. have shown that a cluster of polymorphisms in APOE, SOAT1, the APOE 5'-untranslated region, OLR1, CYP46A1, LPL, LIPA, and APOA4 conferred significant (p=0.0002) susceptibility for AD (25), which was confirmed by the current study which showed that patients with LPL polymorphism in the homozygous state had a greater risk for developing LOAD. The gene discussed is CYP46A1; the disease is Alzheimer disease.