Interestingly, the core promoter we identified in breast cancer cells, between −923 and −565 upstream the initiation codon, overlaps with the core promoter found in melanoma (−833/−519) [24] and neuroblastoma (−1190/−690) [27] but not with the one found in glioblastoma (−1330/−1190) [26], suggesting a tissue-specific regulation of ST8SIA1. The gene discussed is ST8SIA1; the disease is melanoma.