We generated an in vitro system by infection of B103 rat neuroblastoma cells with lentiviral constructs harboring human wild type α-Syn (LV-α-syn), mutations A53T (LV-α-syn-A53T) or A30P (LV-α-syn-A30P), Tom40 (LV-Tom40) or a combination of these constructs. The gene discussed is TOMM40; the disease is neuroblastoma.