GFAP and ischemic stroke: [1]–[4] GFAP is released rapidly in case of an expanding parenchymal bleeding in the brain leading to immediate cell destruction, whereas it is detected with delay in case of ischemic stroke (IS), where necrosis and cellular disintegration do not occur before 6–12 h after symptom onset. The different kinetics of GFAP release in ICH and IS, respectively, may allow for an early, sensitive and specific distinction between the two major entities of stroke, potentially facilitating the triage of patients and fostering super early implementation of individually targeted therapies [4].