Following the development of GPU-based GMDR-GPU program, we analyzed WTCCC dataset for T2D phenotype and our obtained results not only confirmed some earlier findings (such as the well-documented associations of TCF7L2, TSPAN8, and FTO variants with T2D) but also identified three more susceptibility genes (i.e., L3MBTL3, CELF4, and RUNX1) that have not been associated with T2D before. This evidence concerns the gene TSPAN8 and type 2 diabetes mellitus.