Further mapping and bioinformatics analysis of the 24 core SNPs revealed that they are located in six genes (Table 4), with 2 SNPs in the l(3)mbt-like 3 gene (L3MBTL3) on chromosome 6; 8 in the transcription factor 7-like 2 gene (TCF7L2) on chromosome 10; 1 in the tetraspanin 8 gene (TSPAN8) on chromosome 12; 6 in the fat mass and obesity-associated gene (FTO) on chromosome 16; 2 in the CUGBP, Elav-like family member 4 gene (CELF4) on chromosome 16; and 5 in the runt-related transcription factor 1 gene (RUNX1) on chromosome 21. The gene discussed is TSPAN8; the disease is obesity due to melanocortin 4 receptor deficiency.