RUNX2 and acute myeloid leukemia: All these genes play a well-documented role in the transformation of myeloid cells and are frequently involved in myeloid leukemia.[23]–[26] Interestingly, the activity of Meis and Hox genes renders mouse CMP cells susceptible to MN1 overexpression [22], while MN1 (ref [7]) or Runx2 (ref [26]) overexpression cooperates with Cbfb-SMMHC-induced mouse AML.