The objective of the present study was to evaluate the effects of small-molecule antagonists of the Tcf/ß-catenin complex (PKF 115–584 and CGP049090) on cell proliferation, migration, and invasion of endometrial and endometriotic epithelial and stromal cells obtained from patients with and without endometriosis (controls) throughout the menstrual cycle. The gene discussed is HNF4A; the disease is endometriosis.