Our previous results with Transient Receptor Potential Vanilloid 1 (TRPV1) capsaicin receptor deficient mice revealed that the activation of this ion channel by bradykinin, lipoxygenase products and prostanoids enhances the adjuvant-induced oedema, mechanical hyperalgesia and inflammatory reaction in this murine model of arthritis [32]. The gene discussed is TRPV1; the disease is arthritic joint disease.