High Cry1 expression may inhibit the ability of Wee1 to promote cell proliferation, thereby providing a survival advantage for CRC [24].Moreover, the Cry1 protein is known to complex with adenylyl cyclase, and overexpression of Cry1 reduces cAMP production in response to PGE2, isoproterenol, and even the direct adenylyl cyclase activator, forskolin [25]. The gene discussed is WEE1; the disease is colorectal carcinoma.