PVT1 and neoplasm: The gene-expression analysis on lymphocytes from Italian healthy subjects showed a possible eQTL for PVT1. Functional studies are needed to clarify the link between PVT1-associated SNPs, gene expression regulation and cancer risk taking into account that in our study PVT1 seems to act only at an early stage of carcinogenesis as its deregulation has not been observed at later stages in tumor tissue [22].